Robin van Persie will miss the second leg of Arsenal's Champions League last-16 tie against Barcelona on March 8
Van Persie has been ruled out for at least three weeks after sustaining the injury in Sunday's Carling Cup final defeat by Birmingham.However, Arsene Wenger described Cesc Fabregas as a "possible" for the Nou Camp trip after revealing he is making quick progress in his rehabilitation from a hamstring problem.
Losing Van Persie is a seismic blow to Arsenal's hopes of staging another upset against the Spanish champions.
The in-form 27-year-old Holland striker sustained the injury in the act of scoring Arsenal's equaliser during the 2-1 defeat at Wembley.
The goal was his 13th in 11 games - a haul that includes the equaliser against Barcelona in the first leg, which the Gunners edged 2-1.
